The Case of Unpredictable Anxiety w/ Trudy Scott

Health Mysteries Solved Podcast with Inna Topiler

Anxiety-induced insomnia, ineffective medication, panic attacks all lead us to look at the role neurotransmitters might play in this case of anxiety

The Case: 

  • Lauren is 32 and has been dealing with anxiety most of her life
  • She noticed that her anxiety can be worse during stressful times and during the winter.
  • She was  on anti-anxiety medication but they made her feel flat.
  • She tried meditation for anxiety but this wasn’t enough and didn’t completely resolve the panic attacks. 

The Investigation

Lauren’s situation is pretty common and I knew that we had to get to the root of the problem if we were going to help her deal with her anxiety. I suspected her neurotransmitters were part of the solution so that’s where I started investigating.  

Trudy Scott is a certified nutritionist and food-mood expert. She’s the author of The Anti-anxiety Food Solution: How the Foods You Eat Can Help You Calm Your Anxious Mind, Improve Your Mood and End Cravings and is the host of The Anxiety Summit

Neurotransmitters Role in Anxiety

While anxiety is seldom only caused by neurotransmitters, there are several that can play a role. In this week’s episode, and for Lauren’s case, we look at two neurotransmitters – serotonin and gaba – which are both proven to impact our ability to handle stress and deal with different types of anxiety.

Can Low Serotonin Causes Anxiety?

Most people understand the relationship between serotonin and depression but they don’t realize that it also impacts anxiety. Low serotonin results in a specific type of anxiety, according to Trudy. She explains that it is linked to anxiety that may present as negative self talk, low mood, lack of confidence and self-esteem. Low serotonin can also result in panic attacks, phobias, ruminating thoughts (where you replay past events or constantly re-processing things) obsessive behaviors or obsessive thinking (often lying awake at night thinking about things). Another tell tale sign of low-serotonin-anxiety is afternoon and evening cravings were the only way to calm the anxiety is with eating (fulfilling the craving). Because serotonin naturally slows down during the darker winter months, anxiety can be seasonal. 

Low GABA Triggers Anxiety

Anxiety triggered by low GABA (Gamma-Aminobutyric Acid) presents differently than anxiety caused by low serotonin. Low GABA anxiety is physical. This might present as general stiffness and tension in the body. You may lay awake at night feeling physically tense which stops you from being able to sleep. Often, low GABA suffers will feel tension in the gut, they may even feel sick to their stomach. Unlike those with low-serotonin anxiety who may self-medicate with food, those with low-GABA anxiety are more likely to self-medicate with alcohol. 

Diagnosing Neurotransmitter Triggered Anxiety

There are a few tests (like urinary neurotransmitter tests and platelet serotonin tests) that can determine serotonin or GABA levels that can help determine if this might be the root cause of the anxiety. However, Trudy prefers to use a questionnaire to pinpoint the symptoms and then do a trial. For this, she has patients rank specific anxieties and then gives them a small dose, sublingually, of either GABA or an amino acid that replicates serotonin. She then re-administers the questionnaire. If there is a significant drop in their anxiety response, then she proceeds with a treatment plan. 

Treating Anxiety Caused by Low Serotonin 

Instead of just replacing the serotonin with a supplement, Trudy likes to help the body relearn how to make its own. Each treatment is highly individualized but a common plan would include amino acids including 5HTP and Tryptophan. These amino acids are considered substrates or precursors to us for us to make serotonin. There are some other nutrients that are needed like zinc, vitamin B6, magnesium, that are all cofactors that, together with tryptophan and 5HTP, help us to make our own serotonin.This supplement protocol, should be done along with dietary and lifestyle changes. Whatever caused the serotonin to slow down in the first place needs to also be addressed. This may be things like a gluten sensitivity, dysbiosis, parasites, autoimmune disease  (like Hashimoto’s), or chronic stress.

Treating Anxiety Caused by Low GABA

Again, the treatment needs to be individualized and go hand in hand with diet or lifestyle changes that relate back to the root cause of the lower GABA production. Trudy prefers to use sublingual GABA supplements because its faster and it also ensures that there aren’t any issues with digestion. In this episode, she also addresses the controversial theory that GABA can’t cross the blood/brain barrier. There are different GABA receptors in the body (including muscle and gut) which she outlines as part of the reason that she feels GABA can still be effective. GABA has other benefits such as supporting the endocrine system,  pancreas, liver, and fluoride-induced hypothyroidism. There are also benefits for people with diabetes. 

The Gut Connection to Anxiety

So many things that happen in the gut can cause reduced levels of serotonin and GABA. 95% of our serotonin originates in the gut, so that is the first place to look when trying to determine the root cause of low-serotonin anxiety. Studies have found that 5HTP can improve motility. Poor motility is often linked to gut issues like SIBO (Small Intestinal Bacterial Overgrowth) so an added benefit to treating low-serotonin is that it improves gut health, which we know in turn improves communication through the vagus nerve resulting in decreased depression and anxiety. 

Additionally, studies have shown that lactobacillus rhamnosus probiotics not only affect GABA receptors, they also lowers cortisol. High levels of cortisol are often related to depression and anxiety. So, this probiotic is improving gut health and simultaneously altering GABA and cortisol levels. 

Deficiencies Related to Anxiety

Trudy also tests patient levels of B12, methylmalonic acid, and homocysteine. These can often contribute to anxiety. Constipation may also indicate a B12 deficiency and, as mentioned above, can contribute to anxiety through poor gut health. This may be treated with a B12 supplement.

Cautions About Supplements and Anxiety

Each protocol is highly individualized because there may be other factors to consider. For example, if someone is on an antidepressant or anti-anxiety medication, natural treatments must be monitored carefully. Additionally, if someone has Lyme disease, an auto-immune disease or heavy metal toxicity, the protocol needs to be altered. Some do find that by getting to the root cause, dealing with it, and then retraining the body to produce adequate amounts of serotonin or GABA results in them being able to stop taking medication – but that would need to be determined by the individuals professional health team. 

Mystery Solved

When we looked at Lauren’s symptoms in light of a potential neurotransmitter issues, they pointed directly to low serotonin. Here’s what she was experiencing:  

  • Anxiety
  • Panic attacks or phobias 
  • Feeling worried or fearful 
  • Obsessive thoughts or behaviors 
  • Perfectionism or being overly controlling 
  • Irritability 
  • Anxiety that’s worse in winter 
  • Winter blues 
  • Excessive self-criticism 
  • Low self-esteem and poor self-confidence 
  • Difficulty getting to sleep 
  • Insomnia or disturbed sleep 

We did a trial with tryptophan and after just a few minutes of taking it, she noticed she was feeling calmer and her mind was more quiet. We had our proof. 

We started with 500 mg of tryptophan, twice a day. With no issues at this dosage, we increased it to 1000 mg and she felt great within just a few days! Of course every person is different and so if you are going to try this, please be sure to work with a qualified practitioner that can monitor you and help you find the dose that is right for you since this is not a one size fits all approach. 

Lauran was still having a little trouble falling asleep at night even with the tryptophan. So after 2 weeks on that support, we added a small amount of GABA. I gave Lauren the Liquid GABA from Quicksilver Scientific and she took 4 pumps of that before going to bed. She was able to cut her falling asleep time from one hour to 10 minutes.

Once we had the anxiety symptoms under control, we got to work treating the root cause. We supported her gut and improved her diet (including removing gluten). After 2 months, her symptoms were gone and she didn’t need the tryptophan any longer.

Eliminating Health Mysteries

For Lauren, we were able to get to the root cause in a way that conventional medicine was unable to do. By getting her serotonin and GABA back up, and by dealing with her gut issues we were able to free her of challenges she’d faced her whole life. Anxiety and the unpredictable panic attacks that sometimes come with it can dramatically impact happiness and lifestyle. Imagine the freedom Lauren now feels.  

Could this be the missing clue to anxiety issue for you or someone in your life? Share this episode and take advantage of Trudy’s free virtual summit on anxiety. 


Thanks to my guest Trudy Scott. If you deal with anxiety at any level, Trudy’s virtual Anxiety Summit should be on your calendar and the free guide to amino acids is a must have! Download it here, its free! 

Suggested Products

Quicksilver Scientific GABA (liquid) 




Lactobacillus RhamnosusProbiotics

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Hi, I'm Inna!

I am obsessed with getting to the real root of health mysteries. Whether you are suffering from a major health issue like an autoimmune disease or have nagging and frustrating symptoms like fatigue, stomach discomfort, pain, insomnia, brain fog, PMS, skin issues, etc… they have a big impact on how you live your life. You don’t have to suffer. Together we can change that!